| Reaction Details |
|---|
 | Report a problem with these data |
| Target | von Hippel-Lindau disease tumor suppressor |
|---|
| Ligand | BDBM536203 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | VHL HEK-293 BRET Assay |
|---|
| IC50 | 45400±n/a nM |
|---|
| Citation |  Blaquiere, N; Dragovich, P; Gazzard, LJ; Pillow, T; Staben, ST; Wei, B; Xin, J (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof US Patent US11242344 Publication Date 2/8/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| von Hippel-Lindau disease tumor suppressor |
|---|
| Name: | von Hippel-Lindau disease tumor suppressor |
|---|
| Synonyms: | Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 24136.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P40337 |
|---|
| Residue: | 213 |
|---|
| Sequence: | MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPR
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFR
DAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI
VRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
|
|
|
|---|
| BDBM536203 |
|---|
| n/a |
|---|
| Name | BDBM536203 |
|---|
| Synonyms: | (R)-1-((2S,4R)-2-(5,5-dimethyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one | US11242344, Example 126.1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H26N4O4 |
|---|
| Mol. Mass. | 350.4127 |
|---|
| SMILES | CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(C)(C)N1)c1cc(C)no1 |r,t:13| |
|---|
| Structure | 
|
|---|
Search and Browse
