Reaction Details |
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Target | Protein arginine N-methyltransferase 5 |
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Ligand | BDBM453011 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Assay |
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IC50 | 1.45±n/a nM |
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Citation | Luengo, J; Lin, H; Hawkins, M; Shetty, R; Pitis, P; Saborit Villarroya, G Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) US Patent US11254683 Publication Date 2/22/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 5 |
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Name: | Protein arginine N-methyltransferase 5 |
Synonyms: | 72 kDa ICln-binding protein | ANM5_HUMAN | HRMT1L5 | Histone-arginine N-methyltransferase PRMT5 | IBP72 | JBP1 | Jak-binding protein 1 | PRMT5 | PRMT5/MEP50 complex | Protein arginine N-methyltransferase 5 (PRMT5) | Protein arginine methyltransferase 5 (PRMT5) | SKB1 | SKB1 homolog | SKB1Hs | Shk1 kinase-binding protein 1 homolog |
Type: | Enzyme |
Mol. Mass.: | 72679.99 |
Organism: | Homo sapiens (Human) |
Description: | O14744 |
Residue: | 637 |
Sequence: | MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAK
NRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLP
AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYS
GEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNK
KGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELF
AKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQV
LMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDM
REWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKL
YNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEF
PVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICV
RFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
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BDBM453011 |
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n/a |
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Name | BDBM453011 |
Synonyms: | (2R,3R,4S,5S)-2-(4-amino-7H- pyrrolo[2,3-d]pyrimidin-7-yl)-5- ((R)-6,7-difluoroisochroman-1- yl)tetrahydrofuran-3,4-diol | US10711007, Example 73 | US11214574, Ex# 73 | US11254683, Example 73 |
Type | Small organic molecule |
Emp. Form. | C19H18F2N4O4 |
Mol. Mass. | 404.3674 |
SMILES | Nc1ncnc2n(ccc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)[C@@H]1OCCc2cc(F)c(F)cc12 |r| |
Structure |
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