| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM539995 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Experiment of the compounds on activation of transient transfected PPAR alpha in HEK293 cells |
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| EC50 | 1.33±n/a nM |
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| Citation |  Zhu, J; Song, Z; Long, D; Wang, L; Wang, J Aromatic compound, pharmaceutical composition and use thereof US Patent US11261170 Publication Date 3/1/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM539995 |
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| n/a |
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| Name | BDBM539995 |
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| Synonyms: | (E)-2-(4-(3-(2,7-dimethoxy-quinolin-3-yl)-3-oxo-1-propen-1-yl)-2,6-dimethylphenoxy)-2-methylpropionic acid (TM28) | US11261170, Example 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27NO6 |
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| Mol. Mass. | 449.4957 |
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| SMILES | COc1ccc2cc(C(=O)\C=C\c3cc(C)c(OC(C)(C)C(O)=O)c(C)c3)c(OC)nc2c1 |
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| Structure | 
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