| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Short transient receptor potential channel 6 |
|---|
| Ligand | BDBM542453 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Electrophysiology Assay |
|---|
| IC50 | 14.1±n/a nM |
|---|
| Citation |  Zhang, X; Pan, W; Nikitidis, G; Lindhagen, JS Cyclopentane compounds US Patent US11274091 Publication Date 3/15/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Short transient receptor potential channel 6 |
|---|
| Name: | Short transient receptor potential channel 6 |
|---|
| Synonyms: | TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 106326.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107640 |
|---|
| Residue: | 931 |
|---|
| Sequence: | MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS
DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE
CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI
LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR
KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL
SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR
PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL
ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA
KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS
FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA
IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI
GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL
NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL
KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS
EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE
EKSQNTEDLAELIRELGEKLSMEPNQEETNR
|
|
|
|---|
| BDBM542453 |
|---|
| n/a |
|---|
| Name | BDBM542453 |
|---|
| Synonyms: | 2-[2-(3-amino-1-piperidyl)-4-phenyl-cyclopentoxy] benzonitrile | US11274091, Example 20 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N3O |
|---|
| Mol. Mass. | 361.48 |
|---|
| SMILES | NC1CCCN(C1)C1CC(CC1Oc1ccccc1C#N)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
