| Reaction Details |
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 | Report a problem with these data |
| Target | Short transient receptor potential channel 6 |
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| Ligand | BDBM542458 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Electrophysiology Assay |
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| IC50 | 9.93±n/a nM |
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| Citation |  Zhang, X; Pan, W; Nikitidis, G; Lindhagen, JS Cyclopentane compounds US Patent US11274091 Publication Date 3/15/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Short transient receptor potential channel 6 |
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| Name: | Short transient receptor potential channel 6 |
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| Synonyms: | TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 106326.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107640 |
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| Residue: | 931 |
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| Sequence: | MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS
DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE
CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI
LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR
KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL
SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR
PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL
ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA
KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS
FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA
IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI
GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL
NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL
KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS
EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE
EKSQNTEDLAELIRELGEKLSMEPNQEETNR
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| BDBM542458 |
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| n/a |
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| Name | BDBM542458 |
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| Synonyms: | US11274091, Example 25 | l-[4-(4-fluorophenyl)-2-(5-fluoropyridazin-3-yl)oxy- cyclopentyl]piperidin-3-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24F2N4O |
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| Mol. Mass. | 374.4276 |
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| SMILES | NC1CCCN(C1)C1CC(CC1Oc1cc(F)cnn1)c1ccc(F)cc1 |
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| Structure | 
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