Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK1 [837-1142]

Ligand

BDBM262166

Substrate/Competitor

n/a

Meas. Tech.

In Vitro JAK Kinase Assay

IC50

<10±n/a nM

Citation

Assad, A Combination therapy for treatment of hematological diseases US Patent US11324749 Publication Date 5/10/2022

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK1 [837-1142]

Name:

Tyrosine-protein kinase JAK1 [837-1142]

Synonyms:

Type:

n/a

Mol. Mass.:

35230.04

Organism:

Homo sapiens (Human)

Description:

P23458[837-1142]

Residue:

306

Sequence:

FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDP
EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIM
EFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ
VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT
YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQP
SNRTSF

BDBM262166

n/a

Name

BDBM262166

Synonyms:

5-{3-(cyanomethyl)- 3-[4-(1H-pyrrolo[2,3- b]pyridin-4-yl)-1H- pyrazol-1-yl] azetidin-1-yl}-N- isopropylpyrazine- 2-carboxamide | US10065963, Compound 17 | US10125150, Example 17 | US10336759, # 17 | US10479803, Example 17 | US10513522, Example 34 | US10675284, Example 17 | US11084822, Example 17 | US11130767, # 17 | US11136326, Example 17 | US11214573, Example 34 | US11304949, Compound 17 | US11324749, Comp. No. 17 | US11406640, Comp. No. 17 | US11596632, Comp. No. 17 | US11918581, Compound 17 | US20240058343, Compound 17 | US9611269, Example 34 | US9708333, 17 | US9732097, Example 17

Type

Small organic molecule

Emp. Form.

C23H23N9O

Mol. Mass.

441.4884

SMILES

CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12

Structure