| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta |
|---|
| Ligand | BDBM573136 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PDE Enzyme Assay |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Camp, NP; Hamdouchi, C; Lineswala, JP; Morphy, JR; Shi, Q Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors US Patent US11453673 Publication Date 9/27/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta |
|---|
| Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta |
|---|
| Synonyms: | PDE 6AB | PDE6AB | Rod cGMP-specific 3'''''''',5''''''''-cyclic phosphodiesterase alpha/beta | Rod cGMP-specific 3'''',5''''-cyclic phosphodiesterase alpha/beta | Rod cGMP-specific 3'',5''-cyclic phosphodiesterase alpha/beta | Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha/beta |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
|---|
| Synonyms: | PDE6A | PDE6A_HUMAN | PDEA | Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 99531.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1347866 |
|---|
| Residue: | 860 |
|---|
| Sequence: | MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
QPGGNPSPGGATTSKSCCIQ
|
|
|
|---|
| Component 2 |
| Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
|---|
| Synonyms: | GMP-PDE beta | PDE6B | PDE6B_HUMAN | PDEB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 98308.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_105761 |
|---|
| Residue: | 854 |
|---|
| Sequence: | MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL
ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
SGPRTPDGREIVFYKVIDYVLHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC
NGGPAPKSSTCCIL
|
|
|
|---|
| BDBM573136 |
|---|
| n/a |
|---|
| Name | BDBM573136 |
|---|
| Synonyms: | US11453673, Example 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H26N4O |
|---|
| Mol. Mass. | 314.4252 |
|---|
| SMILES | CCCCCn1c(C)c(C)n2c(nnc2c1=O)C1(CC1)C1CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
