Reaction Details |
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Target | Serine/threonine-protein kinase LATS1 |
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Ligand | BDBM574285 |
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Substrate/Competitor | n/a |
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Meas. Tech. | LATS1 Biochemical Assay: Homogenous Time Resolved Fluorescence (HTRF) Assay |
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IC50 | 2.00±n/a nM |
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Citation | Behnke, D; Berenshteyn, F; Hao, X; Hoffman, T; Jin, Q; Lacoste, A; Lee, C; Liu, J; Liu, Y; Maibaum, JK; Mo, T; Pan, J; Qu, X; Tchorz, J; Xie, YF; Yan, S; Zou, Y 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors US Patent US11458138 Publication Date 10/4/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase LATS1 |
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Name: | Serine/threonine-protein kinase LATS1 |
Synonyms: | LATS1 | LATS1_HUMAN | WARTS |
Type: | PROTEIN |
Mol. Mass.: | 126893.90 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774443 |
Residue: | 1130 |
Sequence: | MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTE
DPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVI
QALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKG
SKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPP
QVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGY
PPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQ
NVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNME
LYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQ
PSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNV
TVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENV
DSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHR
KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC
LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF
VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG
HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAAR
QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM
KVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR
QQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTF
RRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV
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BDBM574285 |
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n/a |
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Name | BDBM574285 |
Synonyms: | US11458138, Example 114 |
Type | Small organic molecule |
Emp. Form. | C26H26N6O2S |
Mol. Mass. | 486.589 |
SMILES | Cc1c(-c2nc(NC(C)(C)C)c3ccncc3n2)c2cccnc2n1S(=O)(=O)c1ccc(C)cc1 |
Structure |
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