Reaction Details |
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Target | Tyrosine-protein kinase BTK |
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Ligand | BDBM588142 |
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Substrate/Competitor | n/a |
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Meas. Tech. | BTK and EGFR in Vitro Assay |
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IC50 | 6.01±0.579 nM |
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Citation | Henry, Jr., KJ; Khilevich, A; Kuklish, SL; Partridge, KM; Quimby, SJ BTK inhibitor compounds US Patent US11542249 Publication Date 1/3/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase BTK |
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Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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BDBM588142 |
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n/a |
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Name | BDBM588142 |
Synonyms: | 1-[3-[[5-[2-(3- chloroanilino) pyrimidin-5-yl]-3- pyridyl]amino]azetidin- 1-yl]prop-2-en-1-one | US11542249, Example 15 |
Type | Small organic molecule |
Emp. Form. | C22H21ClN6O |
Mol. Mass. | 420.895 |
SMILES | Clc1cccc(Nc2ncc(cn2)-c2cncc(N[C@H]3CCN(C3)C(=O)C=C)c2)c1 |r| |
Structure |
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