| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM479527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Affinities to Different Adenosine Receptors |
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| IC50 | 0.900±n/a nM |
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| Citation |  Qi, C; Tsui, H; Zeng, Q; Yang, Z; Zhang, X Pyrazine compounds and uses thereof US Patent US11571420 Publication Date 2/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36520.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30542 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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| BDBM479527 |
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| n/a |
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| Name | BDBM479527 |
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| Synonyms: | 3-amino-5-(4-fluorophenyl)-6-(3- methyl-3H-benzo[d]imidazol-5-yl)-N- ((3-(2-(methylamino)ethoxy)pyridin-2-yl) methyl)pyrazine-2-carboxamide | US10898481, Compound 115 | US11571420, Compound 115 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27FN8O2 |
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| Mol. Mass. | 526.5648 |
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| SMILES | CNCCOc1cccnc1CNC(=O)c1nc(-c2ccc3ncn(C)c3c2)c(nc1N)-c1ccc(F)cc1 |
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| Structure | 
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