Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase Mer

Ligand

BDBM396967

Substrate/Competitor

n/a

Meas. Tech.

TAM Enzymatic Assay

IC50

>100±n/a nM

Citation

Li, Y; Wang, X; He, C Pyrrolotriazine compounds as TAM inhibitors US Patent US11591338 Publication Date 2/28/2023

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase Mer

Name:

Tyrosine-protein kinase Mer

Synonyms:

Type:

PROTEIN

Mol. Mass.:

110234.77

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1498723

Residue:

999

Sequence:

MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM

BDBM396967

n/a

Name

BDBM396967

Synonyms:

N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl}-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | US10442810, Example 29 | US10844069, Example 29 | US11591338, Example 29 | US9981975, Example 29

Type

Small organic molecule

Emp. Form.

C31H26FN7O2

Mol. Mass.

547.5822

SMILES

Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-2.34,12.11,;-1.57,13.44,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-3.88,14.78,;-4.65,13.44,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)|

Structure