Reaction Details |
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Target | Rho-associated protein kinase 1 [1-535] |
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Ligand | BDBM598551 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay) |
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IC50 | 332±n/a nM |
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Citation | Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent US11613531 Publication Date 3/28/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Rho-associated protein kinase 1 [1-535] |
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Name: | Rho-associated protein kinase 1 [1-535] |
Synonyms: | ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1) |
Type: | Enzyme |
Mol. Mass.: | 62220.48 |
Organism: | Homo sapiens (Human) |
Description: | aa 1-535 |
Residue: | 535 |
Sequence: | MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
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BDBM598551 |
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n/a |
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Name | BDBM598551 |
Synonyms: | 2-(3-phenyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)phenyl)pyrimidin-4-amine | US11613531, Example 18 |
Type | Small organic molecule |
Emp. Form. | C26H26N6 |
Mol. Mass. | 422.5248 |
SMILES | C1CNC(CN(C1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1)c1ccccc1 |
Structure |
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