Reaction Details |
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Target | Rho-associated protein kinase 2 [1-552] |
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Ligand | BDBM598581 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay) |
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IC50 | 0.900±n/a nM |
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Citation | Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent US11613531 Publication Date 3/28/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Rho-associated protein kinase 2 [1-552] |
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Name: | Rho-associated protein kinase 2 [1-552] |
Synonyms: | KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2) |
Type: | Enzyme |
Mol. Mass.: | 63353.50 |
Organism: | Homo sapiens (Human) |
Description: | aa 1-552 |
Residue: | 552 |
Sequence: | MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT
AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQI
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BDBM598581 |
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n/a |
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Name | BDBM598581 |
Synonyms: | N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methylpyrimidin-4-yl)-1H-indazol-5-amine | US11613531, Example 211 |
Type | Small organic molecule |
Emp. Form. | C17H19N7 |
Mol. Mass. | 321.3797 |
SMILES | Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1CC2CC1CN2 |
Structure |
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