| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Granzyme B |
|---|
| Ligand | BDBM605182 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | >5000±n/a nM |
|---|
| Citation |  Bilcer, GM; Kelly, TA Granzyme B directed imaging and therapy US Patent US11667645 Publication Date 6/6/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Granzyme B |
|---|
| Name: | Granzyme B |
|---|
| Synonyms: | CGL1 | CSPB | CTLA1 | GRAB_HUMAN | GRB | GZMB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 27735.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_469245 |
|---|
| Residue: | 247 |
|---|
| Sequence: | MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
KKTMKRY
|
|
|
|---|
| BDBM605182 |
|---|
| n/a |
|---|
| Name | BDBM605182 |
|---|
| Synonyms: | (2S,5S)-5-{(2S,3S)-2-[2-(2-Fluoro- ethoxy)-acetylamino]-3-methyl- pentanoylamino}-4-oxo-1,2,4,5,6,7- hexahydro-azepino[3,2,1-hi]indole-2- carboxylic acid 4-methyl-benzylamide | US11667645, Compound C129 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H39FN4O5 |
|---|
| Mol. Mass. | 566.6636 |
|---|
| SMILES | CC[C@H](C)[C@H](NC(=O)COCCF)C(=O)N[C@H]1CCc2cccc3C[C@H](N(c23)C1=O)C(=O)NCc1ccc(C)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
