| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C eta type |
|---|
| Ligand | BDBM511486 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Kinase Activity Assay |
|---|
| IC50 | 436±n/a nM |
|---|
| Citation |  deLong, MA; Carlson, E; Kopczynski, C; Sturdivant, JM; Lichorowic, C Isoquinoline-steroid conjugates and uses thereof US Patent US11691950 Publication Date 7/4/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C eta type |
|---|
| Name: | Protein kinase C eta type |
|---|
| Synonyms: | KPCL_HUMAN | PKC-L | PKCL | PRKCH | PRKCL | Protein Kinase C, eta | Protein kinase C, PKC; classical/novel | nPKC-eta |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 77844.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
|---|
| Residue: | 683 |
|---|
| Sequence: | MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTK
QKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEG
WVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLR
QPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRF
GINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAV
ELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRV
LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF
CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL
KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM
GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL
TQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDE
GHLPMINQDEFRNFSYVSPELQP
|
|
|
|---|
| BDBM511486 |
|---|
| n/a |
|---|
| Name | BDBM511486 |
|---|
| Synonyms: | US11059789, Example 19 | US11691950, Example 19 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C45H49N3O9 |
|---|
| Mol. Mass. | 775.8853 |
|---|
| SMILES | C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)COC(=O)C1CC1C(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1 |r,c:13,t:9| |
|---|
| Structure | 
|
|---|
Search and Browse
