Reaction Details |
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Target | Interleukin-1 receptor-associated kinase 1 |
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Ligand | BDBM621165 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinase Inhibitory Assay |
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IC50 | 11.0±n/a nM |
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Citation | HOYT, SB; THOMAS, CJ; FINOCCHIO, CJ; STARCZYNOWSKI, DT; TAWA, GJ; GRACIA MALDONADO, G; ROSEBAUM, JS MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF US Patent US20230303563 Publication Date 9/28/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor-associated kinase 1 |
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Name: | Interleukin-1 receptor-associated kinase 1 |
Synonyms: | IRAK | IRAK-1 | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK-1) |
Type: | Enzyme |
Mol. Mass.: | 76536.81 |
Organism: | Homo sapiens (Human) |
Description: | P51617 |
Residue: | 712 |
Sequence: | MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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BDBM621165 |
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n/a |
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Name | BDBM621165 |
Synonyms: | Exemplary Synthetic Procedure #38 | US20230303563, Compound 269 |
Type | Small organic molecule |
Emp. Form. | C19H20FN5 |
Mol. Mass. | 337.394 |
SMILES | F[C@H]1CNC[C@@H]1Nc1cccc(n1)-c1cnc2cc(ccn12)C1CC1 |r| |
Structure |
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