| Reaction Details |
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 | Report a problem with these data |
| Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 |
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| Ligand | BDBM624501 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of ENPP1 Hydrolysis of 2′,3′-cGAMP |
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| IC50 | <10±n/a nM |
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| Citation |  Cogan, DA; Bettigole, S; Van Berkom, L; Nieczypor, P; Su, M; Folmer, R Imino sulfanone inhibitors of ENPP1 US Patent US11780849 Publication Date 10/10/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 |
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| Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 |
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| Synonyms: | ENPP1 | ENPP1_HUMAN | M6S1 | NPPS | PC1 | PDNP1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 104934.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1448940 |
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| Residue: | 925 |
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| Sequence: | MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPL
EKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNC
RCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINY
SSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKK
CGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEW
YKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLP
KDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLIL
ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSC
REPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNV
FSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVY
TPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYG
RPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPL
SPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTL
LRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKD
TSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSF
YQQRKEPVSDILKLKTHLPTFSQED
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| BDBM624501 |
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| n/a |
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| Name | BDBM624501 |
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| Synonyms: | US11780849, Compound 54b |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27N5O3S |
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| Mol. Mass. | 405.514 |
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| SMILES | COc1cc2ncnc(N3CCC4(CCN(C4)[S@](C)(=N)=O)CC3)c2cc1OC |r| |
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| Structure | 
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