| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B [1-341] |
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| Ligand | BDBM311125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Aurora B Kinase Test |
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| IC50 | 29600±n/a nM |
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| Citation |  Hoffmann, M; Dahmann, G; Gnamm, C; Fandrick, DR; Scott, J; McCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent US10155751 Publication Date 12/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B [1-341] |
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| Name: | Aurora kinase B [1-341] |
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| Synonyms: | AIK2 | AIM1 | AIRK2 | ARK2 | AURB (aa 1-341) | AURKB | AURKB_HUMAN | STK1 | STK12 | STK5 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39070.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4[1-341] |
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| Residue: | 341 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQ
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| BDBM311125 |
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| n/a |
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| Name | BDBM311125 |
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| Synonyms: | US10155751, Example 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21F4N5O2 |
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| Mol. Mass. | 439.4067 |
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| SMILES | C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(CCC(F)(F)F)c1)[C@H]1CNC(=O)C1 |r| |
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| Structure | 
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