Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Diacylglycerol O-acyltransferase 2 |
---|
Ligand | BDBM627190 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | DGAT2 Enzymatic Activity Assay |
---|
IC50 | 17.0±n/a nM |
---|
Citation | Lim, Y; Hugelshofer, CL; Mak, VW; Roane, JP; Sanzone, JR; Shockley, SE; Yen, R Diacylglyceride O-acyltransferase 2 inhibitors US Patent US11787810 Publication Date 10/17/2023 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Diacylglycerol O-acyltransferase 2 |
---|
Name: | Diacylglycerol O-acyltransferase 2 |
Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 43848.90 |
Organism: | Homo sapiens (Human) |
Description: | Q96PD7 |
Residue: | 388 |
Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
|
|
|
BDBM627190 |
---|
n/a |
---|
Name | BDBM627190 |
Synonyms: | 3-[3-(difluoromethoxy)phenyl]-N- [(1S,2S)-2-hydroxycyclohexyl]-1- isopropyl-pyrazolo[4,3-b]pyridine-6- carboxamide | US11787810, Example 40 |
Type | Small organic molecule |
Emp. Form. | C23H26F2N4O3 |
Mol. Mass. | 444.4743 |
SMILES | CC(C)n1nc(-c2cccc(OC(F)F)c2)c2ncc(cc12)C(=O)N[C@H]1CCCC[C@@H]1O |r| |
Structure |
|