Reaction Details |
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Target | Diacylglycerol O-acyltransferase 2 |
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Ligand | BDBM627308 |
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Substrate/Competitor | n/a |
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IC50 | 15.0±n/a nM |
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Citation | Lim, Y; Hugelshofer, CL; Mak, VW; Roane, JP; Sanzone, JR; Shockley, SE; Yen, R Diacylglyceride O-acyltransferase 2 inhibitors US Patent US11787810 Publication Date 10/17/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol O-acyltransferase 2 |
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Name: | Diacylglycerol O-acyltransferase 2 |
Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 43848.90 |
Organism: | Homo sapiens (Human) |
Description: | Q96PD7 |
Residue: | 388 |
Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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BDBM627308 |
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n/a |
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Name | BDBM627308 |
Synonyms: | 3-(2-(difluoromethoxy)-5- fluoropyridin-4-yl)-1-(3- hydroxy-3-methylbutan-2- yl)-N-(3-methyl-1,1- dioxidothietan-3-yl)-1H- pyrazolo[4,3-c]pyridine-6- carboxamide (slower eluting in AD-H column, 25% MeOH (0.1% DEA)/CO2) | US11787810, Example 133b |
Type | Small organic molecule |
Emp. Form. | C22H24F3N5O5S |
Mol. Mass. | 527.517 |
SMILES | CC(n1nc(-c2cc(OC(F)F)ncc2F)c2cnc(cc12)C(=O)NC1(C)CS(=O)(=O)C1)C(C)(C)O |
Structure |
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