| Reaction Details |
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 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 2 |
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| Ligand | BDBM628460 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical (FP) Assay |
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| IC50 | >100000±n/a nM |
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| Citation |  HOFFMAN, RL; VA, PJ; PINCHMAN, JR; DONG, Q; KALDOR, SW SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS US Patent US20230348473 Publication Date 11/2/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly [ADP-ribose] polymerase 2 |
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| Name: | Poly [ADP-ribose] polymerase 2 |
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| Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 66225.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UGN5 |
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| Residue: | 583 |
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| Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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| BDBM628460 |
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| n/a |
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| Name | BDBM628460 |
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| Synonyms: | US11795173, Example 28 | US11795173, Example 33 | US11795173, Example 34 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20F3N7O2 |
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| Mol. Mass. | 471.4351 |
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| SMILES | CNC(=O)c1ccc(N2CCN(Cc3ccc4c([nH]c(=O)c5c(F)cnn45)c3F)CC2)c(F)n1 |
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| Structure | 
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