| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM636139 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Aurora B Kinase Biochemical Assay |
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| IC50 | 673±n/a nM |
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| Citation |  NDUBAKU, C; MOORE, JT; GIBBONS, PA; CHANG, JH; ROMERO, FA; DU, X; KAWAI, H; CIBLAT, S; WANG, H; ALBERT, V; CONSTANTINEAU-FORGET, L; SILVA, H; POLAT, DE; NAYYAR, A; SHORE, DG; WU, K; TAN, J POLO LIKE KINASE 4 INHIBITORS US Patent US20230365537 Publication Date 11/16/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM636139 |
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| n/a |
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| Name | BDBM636139 |
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| Synonyms: | (1R,2S)-2-(3-{[5-(azetidine-1-sulfonyl)-3-methoxypyridin-2-yl]amino}-1H-indaxol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one | US20230365537, Example 268 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26N6O5S |
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| Mol. Mass. | 546.598 |
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| SMILES | COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(Nc5ncc(cc5OC)S(=O)(=O)N5CCC5)n[nH]c4c3)c2c1 |
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| Structure | 
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