| Reaction Details |
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 | Report a problem with these data |
| Target | Mannan-binding lectin serine protease 2 |
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| Ligand | BDBM645075 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Human MASP2 Assay |
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| IC50 | 17.0±n/a nM |
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| Citation |  BIERER, D; FLAMME, I; ZUBOV, D; NEUBAUER, T; TERSTEEGEN, A; BAUMANN, L; JUHL, C; GLATZ, M; DREHER, J; HOLTON, S; XIONG, J; XU, J MASP INHIBITORY COMPOUNDS AND USES THEREOF US Patent US20240010684 Publication Date 1/11/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mannan-binding lectin serine protease 2 |
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| Name: | Mannan-binding lectin serine protease 2 |
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| Synonyms: | 3.4.21.104 | MASP-2 | MASP2 | MASP2_HUMAN | MBL-associated serine protease 2 | Mannan-binding lectin serine protease 2 A chain | Mannan-binding lectin serine protease 2 B chain | Mannose-binding protein-associated serine protease 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75689.43 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117891 |
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| Residue: | 686 |
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| Sequence: | MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
GEAGQYGVYTKVINYIPWIENIISDF
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| BDBM645075 |
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| n/a |
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| Name | BDBM645075 |
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| Synonyms: | US20240010684, Ex. No 51 |
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| Type | Small organic molecule |
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| Emp. Form. | C66H112N16O15S2 |
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| Mol. Mass. | 1433.824 |
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| SMILES | CC[C@H](C)[C@@H]1NC(=O)CCCCCNC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC(C)(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC2(C)C)NC1=O)[C@@H](C)CC)[C@@H](C)CC |r| |
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| Structure | 
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