Reaction Details |
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Target | High affinity nerve growth factor receptor [G667C] |
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Ligand | BDBM647636 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibitory Activity of the Compounds of the Invention Against ROS1, NTRK and ALK and their Drug-Resistant Kinases |
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IC50 | 2.75±n/a nM |
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Citation | LI, J; LIANG, A; NIU, C; WU, Y COMPOUND USED AS KINASE INHIBITOR AND USE THEREOF US Patent US20240025908 Publication Date 1/25/2024 |
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More Info.: | Get all data from this article, Assay Method |
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High affinity nerve growth factor receptor [G667C] |
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Name: | High affinity nerve growth factor receptor [G667C] |
Synonyms: | High affinity nerve growth factor receptor (TrkA)(G667C) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 87544.27 |
Organism: | Homo sapiens (Human) |
Description: | P04629 (G667C) |
Residue: | 796 |
Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
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BDBM647636 |
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n/a |
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Name | BDBM647636 |
Synonyms: | T-07 | US20240025908, Example 4 |
Type | Small organic molecule |
Emp. Form. | C19H19F3N6O |
Mol. Mass. | 404.389 |
SMILES | C[C@@H](Nc1ccn2ncc(C3=NOCC(C)(C)N3)c2n1)c1cc(F)cc(F)c1F |r,t:10| |
Structure |
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