Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 | ||
Ligand | BDBM648235 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzyme Assay | ||
IC50 | >10000±n/a nM | ||
Citation | Finlay, MR; Goldberg, FW; Howard, MR; Ting, AK Purinone compounds and their use in treating cancer US Patent US11884671 Publication Date 1/30/2024 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
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BDBM648235 | |||
n/a | |||
Name | BDBM648235 | ||
Synonyms: | US11884671, Example 12 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H23N7O2 | ||
Mol. Mass. | 405.453 | ||
SMILES | Cc1cc2nnccc2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CC[C@H](O)CC3)c2n1 |r,wU:21.22,24.26,(3.34,-5.24,;3.34,-3.7,;4.68,-2.93,;4.68,-1.39,;6.01,-.62,;6.01,.92,;4.68,1.69,;3.34,.92,;3.34,-.62,;2.01,-1.39,;2.01,-2.93,;.68,-3.7,;-.66,-2.93,;-1.99,-3.7,;-3.33,-2.93,;-3.33,-1.39,;-4.47,-.36,;-6.01,-.36,;-3.84,1.05,;-4.61,2.38,;-2.31,.89,;-1.22,1.97,;.26,1.58,;1.35,2.66,;.95,4.15,;2.04,5.24,;-.53,4.55,;-1.62,3.46,;-1.99,-.62,;-.66,-1.39,)| | ||
Structure |