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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity protein kinase TTK | ||
| Ligand | BDBM648233 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | TTK Enzyme Assay | ||
| IC50 | 316±n/a nM | ||
| Citation |  Finlay, MR; Goldberg, FW; Howard, MR; Ting, AK Purinone compounds and their use in treating cancer US Patent US11884671 Publication Date 1/30/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity protein kinase TTK | |||
| Name: | Dual specificity protein kinase TTK | ||
| Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 97086.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P33981 | ||
| Residue: | 857 | ||
| Sequence: |
| ||
| BDBM648233 | |||
| n/a | |||
| Name | BDBM648233 | ||
| Synonyms: | US11884671, Example 10 | US11884671, Example 13 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23N7O2 | ||
| Mol. Mass. | 405.453 | ||
| SMILES | Cc1cc2nccnc2cc1Nc1ncc2n(C)c(=O)n(C3CCC(O)CC3)c2n1 |(,-3.08,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;;-1.33,-.77,;-1.33,-2.31,;-2.67,-3.08,;-4,-2.31,;-5.47,-2.79,;-5.94,-4.25,;-6.37,-1.54,;-7.91,-1.54,;-5.47,-.29,;-5.94,1.17,;-4.91,2.32,;-5.39,3.78,;-6.89,4.1,;-7.37,5.56,;-7.92,2.96,;-7.45,1.49,;-4,-.77,;-2.67,,)| | ||
| Structure | 
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