| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-5 |
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| Ligand | BDBM651113 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IC50 Determination |
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| IC50 | 140±n/a nM |
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| Citation |  LIN, G; NATHAN, C; KIRKMAN, L; ZHAN, W; MORGAN, T; SATO, K; HARA, R; KAWASAKI, M; IMAEDA, T; TOITA, A; OKAMOTO, R; YUKAWA, T; ASO, K; WONG, T; GINN, JD; FOLEY, MA MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS US Patent US20240043470 Publication Date 2/8/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-5 |
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| Name: | Proteasome subunit beta type-5 |
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| Synonyms: | 20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X |
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| Type: | Protein |
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| Mol. Mass.: | 28480.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 263 |
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| Sequence: | MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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| BDBM651113 |
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| n/a |
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| Name | BDBM651113 |
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| Synonyms: | US20240043470, Compound 1-66 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H38F5N5O5 |
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| Mol. Mass. | 679.6773 |
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| SMILES | FC(F)(F)CNC(=O)[C@@H]1Cc2cccc(Oc3cccc(C[C@H](N4CCCC4=O)C(=O)N[C@@H](CCN4CCC(F)(F)CC4)C(=O)N1)c3)c2 |r| |
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| Structure | 
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