Reaction Details |
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Target | Coagulation factor XII |
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Ligand | BDBM652621 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Determination of FXIIa Inhibition |
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IC50 | 55±n/a nM |
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Citation | CHILDS, ML; DAVIE, RL; EDWARDS, HJ; EVANS, DM; GREVES, WJ; HODGSON, ST; MAZZACANI, A; NORTH, CL; OBARA, AS; ROE, MB; ROOKER, DP; STOCKS, MJ; BIRCH, LM; PICHOWICZ, M; PITTAWAY, R; SMITH, AJ; THROUP, AE; WRIGGLESWORTH, JW; YANG, X; CLARK, DE ENZYME INHIBITORS US Patent US20240059691 Publication Date 2/22/2024 |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor XII |
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Name: | Coagulation factor XII |
Synonyms: | Beta-factor XIIa part 1 | Beta-factor XIIa part 2 | Carboxylesterase 2 (intestine, liver) | Coagulation factor XII | Coagulation factor XII (FXII) | Coagulation factor XIIa heavy chain | Coagulation factor XIIa light chain | F12 | FA12_HUMAN | Factor XIIa | Factor XIIa (fXIIa) | HAF | Hageman factor |
Type: | Enzyme |
Mol. Mass.: | 67810.07 |
Organism: | Homo sapiens (Human) |
Description: | P00748 |
Residue: | 615 |
Sequence: | MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
DVAYYLAWIREHTVS
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BDBM652621 |
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n/a |
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Name | BDBM652621 |
Synonyms: | 5-N-[(4-{[(1-ethylpiperidin-4-yl)oxy]methyl}-2-fluorophenyl)methyl]isoquinoline-1,5- diamine | US20240059691, Example 2201 |
Type | Small organic molecule |
Emp. Form. | C24H29FN4O |
Mol. Mass. | 408.5117 |
SMILES | CCN1CCC(CC1)OCc1ccc(CNc2cccc3c(N)nccc23)c(F)c1 |
Structure |
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