Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Tyrosine-protein kinase JAK2 | ||
Ligand | BDBM658941 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical JAK Kinase Assays | ||
Ki | <0.1±n/a nM | ||
Citation | MCKINNELL, RM; LAM, TM; SMITH, C; GERKEN, P; ALLEGRETTI, P; DOLGONOS, GE; OWENS, C IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS US Patent US20240092758 Publication Date 3/21/2024 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK2 | |||
Name: | Tyrosine-protein kinase JAK2 | ||
Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
Type: | Protein | ||
Mol. Mass.: | 130684.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60674 | ||
Residue: | 1132 | ||
Sequence: |
| ||
BDBM658941 | |||
n/a | |||
Name | BDBM658941 | ||
Synonyms: | US20240092758, Example 58 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H32FN5O2 | ||
Mol. Mass. | 501.5951 | ||
SMILES | CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1F)-c1nc(c[nH]1)C1=CCN(CC1)C(C)C1CC(O)C1 |t:28,(-2.55,.01,;-3.88,.78,;-5.22,.01,;-6.55,.78,;-7.89,.01,;-9.22,.78,;-7.89,-1.53,;-6.55,-2.3,;-5.22,-1.53,;-3.88,-2.3,;-2.55,-1.53,;-1.22,-2.3,;-1.22,-3.84,;-.07,-4.87,;-.7,-6.28,;-2.23,-6.11,;-2.55,-4.61,;-3.88,-3.84,;-5.22,-4.61,;1.43,-4.55,;2.06,-3.14,;3.59,-3.3,;3.91,-4.81,;2.58,-5.58,;4.62,-2.16,;6.13,-2.48,;7.16,-1.33,;6.68,.13,;5.18,.45,;4.15,-.69,;7.71,1.28,;9.22,.95,;7.24,2.74,;7.94,4.11,;6.56,4.81,;6.09,6.28,;5.87,3.44,)| | ||
Structure |