Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK1

Ligand

BDBM659004

Substrate/Competitor

n/a

Meas. Tech.

Biochemical JAK Kinase Assays

0.55±n/a nM

Citation

MCKINNELL, RM; LAM, TM; SMITH, C; GERKEN, P; ALLEGRETTI, P; DOLGONOS, GE; OWENS, C IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS US Patent US20240092758 Publication Date 3/21/2024

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK1

Name:

Tyrosine-protein kinase JAK1

Synonyms:

Type:

Protein

Mol. Mass.:

133293.73

Organism:

Homo sapiens (Human)

Description:

P23458

Residue:

1154

Sequence:

MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK

BDBM659004

n/a

Name

BDBM659004

Synonyms:

US20240092758, Example 121

Type

Small organic molecule

Emp. Form.

C29H32FN5O2

Mol. Mass.

501.5951

SMILES

CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1F)-c1nc(c[nH]1)C1=CCN(CC1)C1CCC(O)CC1 |t:28,(-3.46,.91,;-4.79,1.68,;-6.13,.91,;-7.46,1.68,;-8.8,.91,;-10.13,1.68,;-8.8,-.63,;-7.46,-1.4,;-6.13,-.63,;-4.79,-1.4,;-3.46,-.63,;-2.13,-1.4,;-2.13,-2.94,;-.98,-3.97,;-1.61,-5.38,;-3.14,-5.22,;-3.46,-3.71,;-4.79,-2.94,;-6.13,-3.71,;.52,-3.65,;1.15,-2.25,;2.68,-2.41,;3,-3.91,;1.67,-4.68,;3.71,-1.26,;5.22,-1.58,;6.25,-.44,;5.77,1.03,;4.27,1.35,;3.24,.2,;6.86,2.11,;8.35,1.72,;9.44,2.8,;9.04,4.29,;10.13,5.38,;7.55,4.69,;6.46,3.6,)|

Structure