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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM659012 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biochemical JAK Kinase Assays | ||
| Ki | <0.1±n/a nM | ||
| Citation |  MCKINNELL, RM; LAM, TM; SMITH, C; GERKEN, P; ALLEGRETTI, P; DOLGONOS, GE; OWENS, C IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS US Patent US20240092758 Publication Date 3/21/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
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| BDBM659012 | |||
| n/a | |||
| Name | BDBM659012 | ||
| Synonyms: | US20240092758, Example 129 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H30FN5O2 | ||
| Mol. Mass. | 487.5685 | ||
| SMILES | CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1F)-c1nc(c[nH]1)C1=CCN(C1)[C@@H]1CC[C@H](O)CC1 |r,wU:29.33,32.37,t:28,(-1.66,.04,;-3,.81,;-4.33,.04,;-5.66,.81,;-7,.04,;-8.33,.81,;-7,-1.5,;-5.66,-2.27,;-4.33,-1.5,;-3,-2.27,;-1.66,-1.5,;-.33,-2.27,;-.33,-3.81,;.81,-4.84,;.19,-6.25,;-1.34,-6.09,;-1.66,-4.58,;-3,-3.81,;-4.33,-4.58,;2.32,-4.52,;2.95,-3.12,;4.48,-3.28,;4.8,-4.78,;3.47,-5.55,;5.51,-2.13,;7.04,-2.29,;7.67,-.89,;6.52,.14,;5.19,-.63,;6.68,1.68,;8.11,2.25,;8.33,3.77,;7.12,4.72,;7.34,6.25,;5.69,4.15,;5.47,2.63,)| | ||
| Structure | 
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