| Reaction Details |
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 | Report a problem with these data |
| Target | Protein cereblon |
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| Ligand | BDBM662948 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cereblon Binding Assay |
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| IC50 | 749±n/a nM |
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| Citation |  Bian, Z; Burke, JP; Jia, ZJ; Jiang, X; Katcher, MH; Mali, VR; Marin, VL; Noey, EL; Okano, A; Rivkin, AA; Scholz, SO; Woller, KR; Zhao, X; Adams, AM; Biannic, B; Mortezaei, S; Payette, JN; Zablocki, JA PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE US Patent US20240109877 Publication Date 4/4/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein cereblon |
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| Name: | Protein cereblon |
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| Synonyms: | CRBN | CRBN_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50537.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116917 |
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| Residue: | 442 |
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| Sequence: | MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
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| BDBM662948 |
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| n/a |
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| Name | BDBM662948 |
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| Synonyms: | US20240109877, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H49N11O4 |
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| Mol. Mass. | 771.9098 |
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| SMILES | C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(cc1C)-c1cc(Nc2ccc(cn2)N2CCN(CCc3ccc(cc3)N3CCC(=O)NC3=O)C[C@H]2C)ncn1 |r| |
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| Structure | 
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