Reaction Details |
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Target | Arachidonate 5-lipoxygenase-activating protein |
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Ligand | BDBM323062 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLAP Binding Assay (Test A) |
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IC50 | 210±n/a nM |
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Citation | Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent US10183947 Publication Date 1/22/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Arachidonate 5-lipoxygenase-activating protein |
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Name: | Arachidonate 5-lipoxygenase-activating protein |
Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
Type: | Enzyme |
Mol. Mass.: | 18159.90 |
Organism: | Homo sapiens (Human) |
Description: | P20292 |
Residue: | 161 |
Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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BDBM323062 |
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n/a |
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Name | BDBM323062 |
Synonyms: | (1R,2R and 1S,2S)-N-(4-Methyl-1,3- oxazol-2-yl)-2-[4-(1H-pyrazol-5- yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 45 | US10508119, Example 45 |
Type | Small organic molecule |
Emp. Form. | C21H22N4O3 |
Mol. Mass. | 378.4244 |
SMILES | Cc1coc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2ccn[nH]2)n1 |w:8.7,13.14| |
Structure |
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