| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
|---|
| Ligand | BDBM314979 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Rat and Human Orexin 1 Receptor Radioligand Binding Studies |
|---|
| Ki | 5.00±n/a nM |
|---|
| Citation |  Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US10183953 Publication Date 1/22/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Orexin/Hypocretin receptor type 1 |
|---|
| Name: | Orexin/Hypocretin receptor type 1 |
|---|
| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46817.55 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P56718 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
|
|
|
|---|
| BDBM314979 |
|---|
| n/a |
|---|
| Name | BDBM314979 |
|---|
| Synonyms: | (5-fluoro-2-(pyrimidin-2-yl)phenyl)((1S,4S,6R)-6-(methyl(5-(trifluoromethyl)pyridin-2-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methanone | US10183953, Example 158 | US9611277, Example 158 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21F4N5O |
|---|
| Mol. Mass. | 471.4501 |
|---|
| SMILES | CN(C1CC2CC1N(C2)C(=O)c1cc(F)ccc1-c1ncccn1)c1ccc(cn1)C(F)(F)F |TLB:9:7:2.3:5,THB:1:2:7.8:5| |
|---|
| Structure | 
|
|---|
Search and Browse
