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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Leukotriene A-4 hydrolase | ||
| Ligand | BDBM326939 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| IC50 | 1.79±n/a nM | ||
| Citation |  Bylock, LA Benzodioxane inhibitors of leukotriene production for combination therapy US Patent US9662339 Publication Date 5/30/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Leukotriene A-4 hydrolase | |||
| Name: | Leukotriene A-4 hydrolase | ||
| Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase | ||
| Type: | Hydrolase; metalloprotease | ||
| Mol. Mass.: | 69280.41 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Human recombinant LTA4H. | ||
| Residue: | 611 | ||
| Sequence: |
| ||
| BDBM326939 | |||
| n/a | |||
| Name | BDBM326939 | ||
| Synonyms: | US9662339, 66 | trans-4-({4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl]benzyl}amino) cyclohexanecarboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N2O3 | ||
| Mol. Mass. | 366.4534 | ||
| SMILES | NC(=O)[C@H]1CC[C@@H](CC1)NCc1ccc(cc1)[C@H]1COc2ccccc2O1 |r,wU:6.9,wD:3.2,17.18,(-8.67,3.47,;-7.34,4.23,;-7.34,5.78,;-6,3.47,;-6,1.93,;-4.67,1.15,;-3.33,1.93,;-3.33,3.47,;-4.67,4.23,;-2,1.15,;-2,-.38,;-.67,-1.15,;-.67,-2.69,;.67,-3.46,;2,-2.69,;2,-1.15,;.67,-.38,;3.33,-3.47,;3.33,-5,;4.67,-5.78,;6,-5,;7.34,-5.78,;8.67,-5,;8.67,-3.47,;7.34,-2.69,;6,-3.47,;4.67,-2.69,)| | ||
| Structure | 
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