| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kallikrein-1 |
|---|
| Ligand | BDBM335741 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Inhibitory Assay |
|---|
| IC50 | 8140±n/a nM |
|---|
| Citation |  Edwards, HJ; Evans, DM; Davie, RL; Rooker, DP; Hewison, SJ Bicyclic inhibitors US Patent US9738641 Publication Date 8/22/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kallikrein-1 |
|---|
| Name: | Kallikrein-1 |
|---|
| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28874.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06870 |
|---|
| Residue: | 262 |
|---|
| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
|
|
|
|---|
| BDBM335741 |
|---|
| n/a |
|---|
| Name | BDBM335741 |
|---|
| Synonyms: | (4-Aminomethyl-2-methyl-benzyl)-[1-(2-phenyl-thiazol-4-ylmethyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]-amine | US9738641, 6 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25N5S |
|---|
| Mol. Mass. | 439.575 |
|---|
| SMILES | Cc1cc(CN)ccc1CNc1nccc2n(Cc3csc(n3)-c3ccccc3)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
