Ki Summary

Reaction Details

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Target

Malignant T-cell-amplified sequence 1

Ligand

BDBM345296

Substrate/Competitor

n/a

Meas. Tech.

Assay 4: MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells

IC50

404±n/a nM

Citation

Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019

More Info.:

Get all data from this article, Assay Method

Malignant T-cell-amplified sequence 1

Name:

Malignant T-cell-amplified sequence 1

Synonyms:

MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies

Type:

Enzyme Catalytic Domain

Mol. Mass.:

20563.62

Organism:

Homo sapiens (human)

Description:

n/a

Residue:

181

Sequence:

MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIE
ILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPG
AKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTY
K

BDBM345296

n/a

Name

BDBM345296

Synonyms:

2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclobutylmethoxy)phenyl]pyrazol-3- yl]methoxy]-2-methyl-propanoic acid. 1HNMR (CDCl3): $#948; 1.55 (s, 6H), 1.75- 1.82 (m, 2H), 1.85-1.98 (m, 2H), 2.06- 2.14 (m, 2H), 2.64-2.70 (m, 1H), 3.71 (d, 2H), 4.63 (s, 2H), 5.43 (s, 2H), 6.42 (s, 1H), 6.75-6.92 (m, 4H), 7.20-7.36 (m, 4). | US10202350, Example 42 | US10214492, Example 42 | US11292767, Example 42 | US11724989, Example 42

Type

Small organic molecule

Emp. Form.

C26H29ClN2O4

Mol. Mass.

468.972

SMILES

CC(C)(OCc1cc(-c2cccc(OCC3CCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O

Structure