| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] |
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| Ligand | BDBM347339 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Eidam, HS Compounds as rearranged during transfection (RET) inhibitors US Patent US9789100 Publication Date 10/17/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] |
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| Name: | Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] |
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| Synonyms: | CDHF12 | CDHR16 | PTC | Proto-oncogene tyrosine-protein kinase receptor Ret | Proto-oncogene tyrosine-protein kinase receptor Ret (aa 658-1114) | RET | RET Kinase (aa 658-1114) | RET51 | RET_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 51535.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07949[658-1114] |
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| Residue: | 457 |
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| Sequence: | HCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN
VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS
LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLD
LAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL
TRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
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| BDBM347339 |
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| n/a |
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| Name | BDBM347339 |
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| Synonyms: | 2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(3-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-5-yl)acetamide | US9789100, Example 27 | US9789100, Example 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21F4N3O4 |
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| Mol. Mass. | 467.4135 |
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| SMILES | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)c(F)c1 |
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| Structure | 
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