| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM323631 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro DGAT2 Assay |
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| IC50 | 182±n/a nM |
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| Citation |  Futatsugi, K Diacylglycerol acyltransferase 2 inhibitors US Patent US9789110 Publication Date 10/17/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM323631 |
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| n/a |
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| Name | BDBM323631 |
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| Synonyms: | (R)-2-(2-((2-(3-(2- ethoxyphenoxy)piperidin-1- yl)pyrimidine-5- carboxamido)methyl)phenyl)acetic acid | US10188653, Example 18.3 | US9789110, 18.3 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N4O5 |
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| Mol. Mass. | 490.5509 |
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| SMILES | CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1ccccc1CC(O)=O |
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| Structure | 
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