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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | ||
| Ligand | BDBM350898 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 2440±n/a nM | ||
| Citation |  Martinez Gil, A; Gil Ayuso-Gontan, CB; Perez Fernandez, DI; Garcia Fernandez, AM S-substituted quinazolines and their therapeutic applications for the treatment of diseases mediated by PDE7 US Patent US9796687 Publication Date 10/24/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | |||
| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55514.96 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13946 | ||
| Residue: | 482 | ||
| Sequence: |
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| BDBM350898 | |||
| n/a | |||
| Name | BDBM350898 | ||
| Synonyms: | 8-Chloro-2-ethylthio-3-(2,6-difluorophenyl)-4-oxo-3,4-dihydroquinazoline | US9796687, Compound 18 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H11ClF2N2OS | ||
| Mol. Mass. | 352.786 | ||
| SMILES | CCSc1nc2c(Cl)cccc2c(=O)n1-c1c(F)cccc1F |(6.67,-5.39,;8,-4.62,;8,-3.08,;6.67,-2.31,;5.33,-3.08,;4,-2.31,;2.67,-3.08,;2.67,-4.62,;1.33,-2.31,;1.33,-.77,;2.67,,;4,-.77,;5.33,,;5.33,1.54,;6.67,-.77,;8,,;9.34,-.77,;9.34,-2.31,;10.67,,;10.67,1.54,;9.34,2.31,;8,1.54,;6.67,2.31,)| | ||
| Structure | 
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