| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
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| Ligand | BDBM345260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells |
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| IC50 | 303±n/a nM |
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| Citation |  Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent US10214492 Publication Date 2/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Monocarboxylate transporter 1 |
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| Name: | Monocarboxylate transporter 1 |
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| Synonyms: | MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53956.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1451367 |
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| Residue: | 500 |
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| Sequence: | MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
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| BDBM345260 |
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| n/a |
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| Name | BDBM345260 |
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| Synonyms: | 2-[[5-(4-Chlorophenyl)-1-[(2,4- dichlorophenyl)methyl]pyrazol-3- yl]methoxy]acetic acid 1H NMR (DMSO-d6, 400 MHz) $#948; 3.80 (s, 2H), 4.50 9s, 2H), 5.30 (s, 2H), 6.50 (s, 1H), 6.60-80 (m, 1H), 7.20-70 (m, 6H). | US10202350, Example 6 | US10214492, Example 6 | US11292767, Example 6 | US11724989, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15Cl3N2O3 |
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| Mol. Mass. | 425.693 |
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| SMILES | OC(=O)COCc1cc(-c2ccc(Cl)cc2)n(Cc2ccc(Cl)cc2Cl)n1 |
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| Structure | 
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