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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [342-460] | ||
| Ligand | BDBM362659 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | AlphaScreen Assay | ||
| IC50 | <25±n/a nM | ||
| Citation |  Combs, AP; Sparks, RB Tricyclic heterocycles as bet protein inhibitors US Patent US9834565 Publication Date 12/5/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [342-460] | |||
| Name: | Bromodomain-containing protein 4 [342-460] | ||
| Synonyms: | BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 13783.81 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | a.a. 342-460 (BRD4-BD2) | ||
| Residue: | 119 | ||
| Sequence: |
| ||
| BDBM362659 | |||
| n/a | |||
| Name | BDBM362659 | ||
| Synonyms: | N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]piperidin-4- yl}ethanesulfonamide | US10227359, Example 14 | US9834565, Example 14 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H30N6O4S | ||
| Mol. Mass. | 522.619 | ||
| SMILES | CCS(=O)(=O)NC1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccn4)n1c23 |(-5.87,7.44,;-5.1,6.11,;-3.56,6.11,;-3.56,7.65,;-3.56,4.57,;-2.02,6.11,;-1.25,4.78,;-2.02,3.44,;-1.25,2.11,;.29,2.11,;1.06,3.44,;.29,4.78,;1.06,.77,;2.6,.77,;3.16,-.66,;4.49,-1.43,;4.49,-2.97,;3.16,-3.74,;3.16,-5.28,;1.91,-6.18,;.45,-5.71,;2.39,-7.65,;3.93,-7.65,;4.41,-6.18,;5.87,-5.71,;1.83,-2.97,;.49,-3.74,;-.84,-2.97,;-.84,-1.43,;-2.17,-.66,;-3.51,-1.43,;-4.84,-.66,;-4.84,.88,;-3.51,1.65,;-2.17,.88,;.49,-.66,;1.83,-1.43,)| | ||
| Structure | 
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