| Reaction Details |
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 | Report a problem with these data |
| Target | Focal adhesion kinase 1 [410-689] |
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| Ligand | BDBM418603 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Activity Assay |
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| IC50 | 0.590±n/a nM |
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| Citation |  Luzzio, MJ; Freeman-Cook, KD; Bhattacharya, SK; Hayward, MM; Hulford, CA; Autry, CL; Zhao, X; Xiao, J; Nelson, KL Sulfonyl amide derivatives for the treatment of abnormal cell growth US Patent US10450297 Publication Date 10/22/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Focal adhesion kinase 1 [410-689] |
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| Name: | Focal adhesion kinase 1 [410-689] |
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| Synonyms: | FAK | FAK1 | FAK1_HUMAN | Focal adhesion kinase 1 (FAK) (aa 410-689) | PTK2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 32163.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 410-689 |
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| Residue: | 280 |
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| Sequence: | PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFL
QEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQ
LSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM
APESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPP
TLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEE
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| BDBM418603 |
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| n/a |
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| Name | BDBM418603 |
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| Synonyms: | 3-methoxy-4-{[4-{[3- (methylsulfonyl)benzyl]amino}-5- (trifluoromethyl)pyrimidin-2- yl]amino}benzamide (47) | US10450297, Example 47 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20F3N5O4S |
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| Mol. Mass. | 495.475 |
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| SMILES | COc1cc(ccc1Nc1ncc(c(NCc2cccc(c2)S(C)(=O)=O)n1)C(F)(F)F)C(N)=O |
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| Structure | 
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