Reaction Details |
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Target | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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Ligand | BDBM22113 |
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Substrate/Competitor | BDBM22111 |
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Meas. Tech. | MTAP/MTAN Inhibition Assay |
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pH | 7±n/a |
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Temperature | 295.15±n/a K |
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Ki | 0.048±0.003 nM |
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Km | 430±n/a nM |
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Comments | Ki is the dissociation constant for the first step in the two-step binding characteristic of slow-onset tight-binding inhibition. |
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Citation | Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem51:948-56 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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Name: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
Synonyms: | 5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA |
Type: | Enzyme |
Mol. Mass.: | 24347.14 |
Organism: | Escherichia coli (strain K12) |
Description: | P0AF12 |
Residue: | 232 |
Sequence: | MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGAT
LLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFK
ADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAH
VCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
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BDBM22113 |
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BDBM22111 |
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Name | BDBM22113 |
Synonyms: | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(9-Deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine, 7 | DADMe-ImmA-Me | MT-DADMe-ImmA |
Type | n/a |
Emp. Form. | C13H19N5OS |
Mol. Mass. | 293.388 |
SMILES | CSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O |r| |
Structure |
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