| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
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| Ligand | BDBM376668 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Vechorkin, O; Li, Y; Sokolsky, A; Wang, A; Zhu, W; Zhuo, J Heterocyclic compounds useful as pim kinase inhibitors US Patent US9920032 Publication Date 3/20/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-2 |
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| Name: | Serine/threonine-protein kinase pim-2 |
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| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 34185.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P1W9 |
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| Residue: | 311 |
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| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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| BDBM376668 |
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| n/a |
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| Name | BDBM376668 |
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| Synonyms: | N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl}-5-fluoro-3-[(3,R)-3-fluoropiperidin-1-yl]quinoline-8-carboxamide | US10450296, Example 2 | US11053215, Example 2 | US9920032, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31F2N5O |
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| Mol. Mass. | 479.5647 |
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| SMILES | C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCC[C@@H](F)C1 |r| |
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| Structure | 
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