Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase pim-2

Ligand

BDBM377197

Substrate/Competitor

n/a

Meas. Tech.

Pim Enzyme Assays

IC50

<100±n/a nM

Citation

Xue, C; Feng, H; Li, Y; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent US10265307 Publication Date 4/23/2019

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase pim-2

Name:

Serine/threonine-protein kinase pim-2

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

34185.93

Organism:

Homo sapiens (Human)

Description:

Q9P1W9

Residue:

311

Sequence:

MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP

BDBM377197

n/a

Name

BDBM377197

Synonyms:

N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide | US10265307, Example 45-1 | US10517858, Example 45 (Diastereoisomer 1) | US10828290, Example 45 (Diastereoisomer 1) | US11229631, Example 45 Diastereoisomer 1

Type

Small organic molecule

Emp. Form.

C26H26F3N5O2

Mol. Mass.

497.5121

SMILES

C[C@@H]1C[C@H](N)CN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:12.13,3.3,1.0,(-.15,3.29,;-1.48,2.52,;-2.82,3.29,;-4.15,2.52,;-5.48,3.29,;-4.15,.98,;-2.82,.21,;-1.48,.98,;-2.82,-1.33,;-4.15,-2.1,;-5.61,-1.62,;-6.52,-2.87,;-5.61,-4.11,;-6.01,-5.6,;-4.15,-3.64,;-2.82,-4.41,;-1.48,-3.64,;-1.48,-2.1,;-.15,-1.33,;1.18,-2.1,;1.18,-3.64,;2.52,-1.33,;3.85,-2.1,;5.19,-1.33,;5.19,.21,;6.52,.98,;3.85,.98,;2.52,.21,;3.85,2.52,;2.52,3.29,;1.18,2.52,;2.52,4.83,;3.85,5.6,;5.19,4.83,;5.19,3.29,;6.52,2.52,)|

Structure