| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity nerve growth factor receptor |
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| Ligand | BDBM249330 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Measurement of TrkA Kinase-Inhibiting Activity Using Human TrkA-Expressing Cells |
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| IC50 | 2.00±n/a nM |
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| Citation |  Takeuchi, J; Itadani, S; Hashimura, K; Ikura, M; Higashino, M; Yasuhiro, T; Nagaura, T Trk-inhibiting compound US Patent US10300060 Publication Date 5/28/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity nerve growth factor receptor |
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| Name: | High affinity nerve growth factor receptor |
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| Synonyms: | 2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA |
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| Type: | n/a |
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| Mol. Mass.: | 87498.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04629 |
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| Residue: | 796 |
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| Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
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| BDBM249330 |
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| n/a |
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| Name | BDBM249330 |
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| Synonyms: | US10300060, Example 15-58 | US10765676, Example 15-58 | US9463192, 15-58 | US9763943, 15-58 | US9993479, 15-58 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H20F4N6O2 |
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| Mol. Mass. | 560.5017 |
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| SMILES | Nc1ncc(F)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-c3ccccc3)C(F)(F)F)cn2)cc1 |
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| Structure | 
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