Ki Summary

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Target

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Ligand

BDBM392043

Substrate/Competitor

n/a

Meas. Tech.

RORgamma Gal4 Reporter Gene Assay (REN)

IC50

6.31±n/a nM

Citation

Gege, C; Steeneck, C; Kinzel, O; Kleymann, G; Hoffmann, T Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] US Patent US10301272 Publication Date 5/28/2019

More Info.:

Get all data from this article, Assay Method

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Name:

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Synonyms:

Type:

Protein

Mol. Mass.:

55831.73

Organism:

Homo sapiens (Human)

Description:

P51449-2

Residue:

497

Sequence:

MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGA
QGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCH
LEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPE
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFSTETESPVGLSK

BDBM392043

n/a

Name

BDBM392043

Synonyms:

US10301272, Example 6/41

Type

Small organic molecule

Emp. Form.

C26H35Cl2N3O5S3

Mol. Mass.

636.674

SMILES

CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)S(C)(=O)=O)c(Cl)c1Cl |r,wU:27.28,wD:29.33,(8.18,-4.16,;7.41,-2.83,;5.87,-2.83,;6.64,-4.16,;8.18,-1.49,;7.41,-.16,;7.41,1.38,;8.75,.61,;5.87,-.16,;5.1,-1.49,;3.56,-1.49,;2.79,-.16,;1.25,-.16,;.35,1.09,;-1.12,.61,;-1.12,-.93,;.35,-1.41,;.75,-2.89,;-.34,-3.98,;-1.83,-3.58,;-2.92,-4.67,;-2.52,-6.16,;-1.03,-6.56,;.06,-5.47,;-2.21,1.7,;-1.81,3.19,;-3.69,1.3,;-4.78,2.39,;-6.32,2.39,;-6.32,3.93,;-4.78,3.93,;-7.41,5.02,;-7.41,6.56,;-8.75,4.25,;-7.41,3.48,;3.56,1.17,;2.79,2.51,;5.1,1.17,;5.87,2.51,)|

Structure