Ki Summary

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Target

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Ligand

BDBM392044

Substrate/Competitor

n/a

Meas. Tech.

RORgamma Gal4 Reporter Gene Assay (FRET)

IC50

63.1±n/a nM

Citation

Gege, C; Steeneck, C; Kinzel, O; Kleymann, G; Hoffmann, T Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] US Patent US10301272 Publication Date 5/28/2019

More Info.:

Get all data from this article, Assay Method

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Name:

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Synonyms:

Type:

Protein

Mol. Mass.:

55831.73

Organism:

Homo sapiens (Human)

Description:

P51449-2

Residue:

497

Sequence:

MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGA
QGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCH
LEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPE
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFSTETESPVGLSK

BDBM392044

n/a

Name

BDBM392044

Synonyms:

US10301272, Example 6/42

Type

Small organic molecule

Emp. Form.

C26H35Cl2N3O5S3

Mol. Mass.

636.674

SMILES

CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@H](C2)S(C)(=O)=O)c(Cl)c1Cl |r,wU:27.28,29.33,(8.29,-4.16,;7.52,-2.83,;5.98,-2.83,;6.75,-4.16,;8.29,-1.49,;7.52,-.16,;7.52,1.38,;8.85,.61,;5.98,-.16,;5.21,-1.49,;3.67,-1.49,;2.9,-.16,;1.36,-.16,;.45,1.09,;-1.01,.61,;-1.01,-.93,;.45,-1.41,;.85,-2.89,;-.24,-3.98,;-1.73,-3.58,;-2.82,-4.67,;-2.42,-6.16,;-.93,-6.56,;.16,-5.47,;-2.1,1.7,;-1.71,3.19,;-3.59,1.3,;-4.68,2.39,;-6.22,2.39,;-6.22,3.93,;-4.68,3.93,;-7.31,5.02,;-7.31,6.56,;-8.85,5.02,;-8.08,3.68,;3.67,1.17,;2.9,2.51,;5.21,1.17,;5.98,2.51,)|

Structure