Ki Summary

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Target

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Ligand

BDBM392110

Substrate/Competitor

n/a

Meas. Tech.

RORgamma Gal4 Reporter Gene Assay (FRET)

IC50

126±n/a nM

Citation

Gege, C; Steeneck, C; Kinzel, O; Kleymann, G; Hoffmann, T Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] US Patent US10301272 Publication Date 5/28/2019

More Info.:

Get all data from this article, Assay Method

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Name:

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Synonyms:

Type:

Protein

Mol. Mass.:

55831.73

Organism:

Homo sapiens (Human)

Description:

P51449-2

Residue:

497

Sequence:

MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGA
QGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCH
LEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPE
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFSTETESPVGLSK

BDBM392110

n/a

Name

BDBM392110

Synonyms:

US10301272, Example 9/2

Type

Small organic molecule

Emp. Form.

C27H34F3N3O5S2

Mol. Mass.

601.701

SMILES

CC(C)(C)NS(=O)(=O)c1ccc(cc1C(F)(F)F)-c1sc(nc1CC1CCCCC1)C(=O)N[C@H]1C[C@@H](C1)C(O)=O |r,wU:33.35,wD:35.40,(6.19,.46,;7.67,.06,;7.28,1.55,;8.76,1.15,;8.07,-1.42,;6.98,-2.51,;6.59,-4,;8.07,-3.6,;5.5,-2.11,;5.1,-.63,;3.61,-.23,;2.52,-1.32,;2.92,-2.8,;4.43,-3.34,;4.83,-4.83,;5.22,-6.32,;6.36,-4.92,;3.34,-5.22,;1.03,-.92,;.56,.55,;-.98,.55,;-1.46,-.92,;-.21,-1.82,;-.21,-3.36,;-1.55,-4.13,;-2.88,-3.36,;-4.21,-4.13,;-4.21,-5.67,;-2.88,-6.44,;-1.55,-5.67,;-2.07,1.64,;-1.67,3.12,;-3.56,1.24,;-4.65,2.33,;-6.19,2.33,;-6.19,3.87,;-4.65,3.87,;-7.28,4.96,;-8.76,4.56,;-6.88,6.44,)|

Structure